MSDS Ref. . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. 4 0 obj Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. In large quantities it provides dietary bulk and may lead to a laxative effect. 1.3. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Product Name: Microcrystalline Cellulose 1.2. undefined. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Terms and Conditions Compliance Solutions Industries About 3E News & Events . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. If you are already a ChemPoint customer then sign up for access to our online ordering website. It is hygroscopic and insoluble in water. (1962). . Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. High performance lubricant that brings more to the tablet. 1 0 obj No. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Avicel RC-591 & CL-611 - Description. Avicel PC 611 (FMC Biopolymer) Supplied by. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Product Name: Microcrystalline Cellulose E460 1.2. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. common form is used in vitamin supplements or tablets. Find answers in our support articles. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. HMo@9, U Q!R/1*;` Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Gloves, eye protection and a dust mask should be used. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. ( This Microcrystalline Cellulose . Regulatory Information The most. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. : 1. Revision No. <> Safety Data Sheet for Cellulose microcrystalline 102331. (Microcrystalline Cellulose Market Pr. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Learn about FMC's industry leading goal of net-zero emissions by 2035. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. JFIF ` ` ZExif MM * J Q Q Q C Validity Area. Microcrystalline Cellulose NF. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. No. Catalog Number 102331. Microcrystalline cellulose is a commonly used excipient in the . ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. cas:9000-11-7 msds Carboxymethyl cellulose. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Superior Performance: Provides excellent water uptake and rapid swelling . MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. There may be more fiber in your food than you realized. Van Veen, G.K. Bolhuis, Y.S. Explore how we work and why we apply science and creativity for a better world to everything we do. /Contents 4 0 R Packaging: 34 x 50 kgs fiber drums. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? SUBSTANCE IDENTIFICATION 1.1. CAS #: 9004-34-6 . 0.25 - 0.37. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Avicel PC 611 (FMC Biopolymer) . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. X\o^ Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Protect them from sunshine or rain. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P PDF (28.38 mb) 2022 Corporate Fact Sheet. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Avicel PH-200 microcrystalline cellulose NF, Ph. q9;v80 Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Product and Company Identification . pH 6.0 to 8.0 . For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. Revision No. PDF (4.11 mb) Footer menu 1. <> endobj cas:9032-51-3 msds CELLULOSE PAB. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. 2008-2023 ChemPoint. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. % cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. MATERIAL SAFETY DATA SHEET Version: 1.0 1. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Quick Links. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. 1 0 obj Home. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Instead, they obtained a stable colloidal suspension. Molecular weight: Not Applicable 1.5. ( endobj 1 0 obj Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. gac74 [#B6`Wnw7 Medium size standard MCC grade, suited for the majority of directly compressible actives. We know that our customers need to provide reliable and consistent products to their patients. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. SDS. 1.3. [FMC Study Number I92-1464]. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Wu, K. Zuurman, H.W. ChemicalBook. . Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Safety Data Sheet (SDS) Viewer. CoA. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. Cellulose microcrystalline. : 5. G2W4de=u183KGH{ vQ#4:1\wc Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. %PDF-1.4 Avicel Microcrystalline Cellulose: Chemical Identifiers. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Doses up to 30 g per day appear to be . Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Trademarks: Avicel PH-102. q86@on$^X_HuH;3` In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. /Resources 2 0 R Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? : CL-611NF Date Approved: 01/13/2010. FMC Corporation. % Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? % United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. ). Manufacturer: FMC BioPolymer. Biologicals by FMC. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. <> Magazine: Material safety data sheet - FMC Corporation. Created Date: 2/10/2020 8:51:41 PM . xv}O2' H~KEe9>G/,:9\i It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. }o]X4]. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . : 9004-34-6 Date Approved: 01/31/2008 . The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Thus, Avicel contributes no or very few calories to the food system. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. We respect your privacy FMC Privacy Policy. Delivering efficient and robust formulations. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Product Name Cellulose microcrystalline. If breathing is difficult or if . {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream
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